Neuroprotective Propensity of 4-Allylpyrocatechol Derivatives against Oxaliplatin Induced Peripheral Neuropathy

Chemotherapy is used for the treatment of rapidly growing cell diseases in body. It most different kinds tumors. can develop neuropathic pain due to damage peripheral nerve cells and it called Chemotherapy-Induced Peripheral Neuropathy (CIPN). In this study, we have reported protective effects 4-allyl pyrocatechol (4-APC) its derivatives from biochemical functional deficits associated with oxaliplatin (OP) induced neuropathy. The animals were submitted mechanical thermal hyperalgesia tests, after OP three times weekly at 0.20 mg/kg 4-APC (10 & 30 mg/kg). parameters evaluated during period end treatment. significantly prevented mice behavioural alterations OP-induced Thus, conclude use might reduce number patients who painful